T2 Protect AD Study at University of Kentucky, Sanders-Brown Center on Aging

Measures Potential Improvement in People with Mild-to-Moderate AD through Use of Troriluzole


The University of Kentucky, Sanders-Brown Center on Aging is now screening participants in a new, national Alzheimer’s disease (AD) clinical research study evaluating the potential benefits of an investigational medicine for people with mild-to-moderate AD.

The Phase 2/3 study, called T2 Protect AD, is evaluating the investigational drug troriluzole (BHV-4157), which may have the potential to protect against, slow down, and even improve memory and thinking problems that increase as Alzheimer’s disease progresses.

Troriluzole is a drug that affects the brain chemical glutamate, which is important for healthy brain function. High glutamate levels in the brain can lead to brain cell dysfunction and disease, including Alzheimer’s disease. Troriluzole normalizes glutamate levels in the brain.

“We are hoping this drug truly makes a difference in this illness,” said Gregory A. Jicha, MD, PhD, professor, department of neurology, University of Kentucky, Sanders-Brown Center on Aging. “We badly need symptomatic therapies for mild to moderate stages of Alzheimer’s disease, when memory and thinking problems interfere with daily life. What really excites me is that troriluzole has the potential to improve cognitive symptoms in people with Alzheimer’s disease.”  

University of Kentucky, Sanders-Brown Center on Aging is one of more than 40 sites in the U.S. participating in the T2 Protect AD study. The study is sponsored by New Haven-based Biohaven Pharmaceutical Holding Company Ltd., and is coordinated by the Alzheimer’s Disease Cooperative Study (ADCS), a large clinical research consortium based at the University of California, San Diego.

The T2 Protect AD trial comes at a time when Alzheimer’s research is focused on earlier stages of the disease and there are not as many clinical trials for people already diagnosed with Alzheimer’s. “Simply put, we need to identify more and better treatments for the millions of people already diagnosed with Alzheimer’s disease and the T2 Protect Study is designed for that population” said Dr. Jicha.

Clinicians at the University of Kentucky, Sanders-Brown Center on Aging are now seeking eligible participants for the T2 Protect AD study. To enroll in T2 Protect AD, participants must be between age 50 and 85, diagnosed with mild-to-moderate Alzheimer’s disease, and already being treated with Alzheimer’s medications for at least three months. Participants must have a study partner who has regular contact with the clinical trial candidate and is able to attend study visits.

For more information about participating in the T2 Protect AD study at University of Kentucky, Sanders-Brown Center on Aging, call (606) 207-7214 or visit T2ProtectAD.

About Alzheimer’s disease

An estimated 5.7 million people in the U.S. suffer from mild-to-moderate AD, with those numbers expected to triple by 2050 without prevention or cure. Alzheimer's disease is a progressive, fatal neurodegenerative dementia that accounts for 60 - 80 percent of dementia cases. Although there are FDA-approved medications for symptomatic treatment of AD, their clinical benefits are generally limited. Novel therapeutic approaches aimed at normalizing synaptic and extra-synaptic glutamate levels, such as troriluzole, may offer the potential for symptomatic benefit in AD by improving cognitive function, as well as the potential for disease modification by preventing the loss of synapses.

About The University of Kentucky, Sanders-Brown Center on Aging

The University of Kentucky, Sanders-Brown Center on Aging opened its doors in 1979 and emerged as a national leader in efforts to improve the quality of life for the elderly through research and education. The  focus of its research is to build a foundation for translational research in degenerative diseases, from bench to bedside, from bedside to practice, from medical centers to communities, in an effort to improve health care outcomes for all who suffer from Alzheimer’s and other degenerative diseases. It is one of the original ten NIH-funded Alzheimer’s Disease Research Centers. For more information, please visit: http://www.uky.edu/coa/


About Biohaven

Biohaven Pharmaceutical Holding Company Ltd. is a clinical-stage biopharmaceutical company with a portfolio of innovative, late-stage product candidates targeting neurological diseases, including rare disorders. Biohaven combined internal development and research with intellectual property licensed from companies and institutions including Bristol-Myers Squibb Company, AstraZeneca AB, Yale University, Catalent, ALS Biopharma LLC and Massachusetts General Hospital. Currently, Biohaven's lead development programs include multiple compounds across its CGRP receptor antagonist and glutamate modulation platforms. The Company's common shares are listed on the New York Stock Exchange and traded under the ticker symbol BHVN. More information about Biohaven is at www.biohavenpharma.com.


About Alzheimer’s Disease Cooperative Study

The Alzheimer’s Disease Cooperative Study (ADCS) was formed in 1991 at the University of California, San Diego. The ADCS is a major initiative for Alzheimer’s disease (AD), addressing treatments for both cognitive and behavioral symptoms. The ADCS seeks to facilitate the discovery, development and testing of new drugs for the treatment of AD. www.adcs.org

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